The Effect of Gland Expression on the Regeneration of Meibomian Gland
Abstract
The goal of this clinical trial is to compare the percentage of meibomian gland (MG) dropout in patients who are treated with additional meibomian gland expression (MGX) and in patients who are not. The main question\[s\] it aims to answer are:
* Does additional MGX reverse MG dropout and support regeneration of MG?
* Does additional MGX have better effect on tear film stability, MG function, lid morphology, tear cytokines than lid hygiene alone?
Methods:
Participants will be randomly assigned into MGX group as a treatment group and control group to assess study outcomes. The basic treatment of the 2 groups included lid hygiene once daily and artificial tear. The treatment duration lasts for 12 weeks. Patients will be examined at baseline, at 4-week, 8-week, 12-week visit for MG dropout percentage, MG morphology, lid margin abnormalities, Meibum assessment, tear film, tear cytokines and pain score to see if additional MGX can regenerate MG better than lid hygiene alone.
Conditions: Meibomian Gland Dysfunction.
Primary outcome: Meibomian gland dropout percentage.
Enrollment: 64 participants.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 64 participants or records.
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