Efficacy of intracameral moxifloxacin versus topical moxifloxacin in preventing acute endophthalmitis after cataract surgery by phacoemulsification.
Abstract
BACKGROUND
Endophthalmitis is an acute infection of anterior and posterior segment of the eye involving aqueous humour and vitreous cavity along with the other structures. It is classified into many types including bacterial, Fungal, protozoal, viral and atypical forms. Most common route of infection is exogenous either after the surgery or traumatic perforation Objectives were of evaluate the efficacy of intracameral moxifloxacin versus topical moxifloxacin in preventing postoperative acute endophthalmitis after cataract surgery by phacoemulsification.
METHODS
Patients undergoing cataract surgery by phacoemulsification are divided into two groups. Group A and group B. Cataract surgery was performed by phacoemulsification in both the groups by the same consultant. Group A was given 0.5% intracameral moxifloxacin 0.1ml undiluted at the end of surgery and Group B received topical moxifloxacin eyedrops and no intracameral medicine at the end of surgery. Post-operative medicine in both the groups was same for 1st twenty-four hours that is topical dexamethasone 0.1%. Postoperative assessment was made on the next day or after twenty-four hours of surgery Our primary outcome was incidence of postoperative acute endophthalmitis.
RESULTS
The study comprised 150 eyes of patients. There were 75 patients in Group A (intracameral moxifloxacin) and 75 patients in Group B (Topical group). Mean age of the patients was 58 years. No case of endophthalmitis was reported in group A…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 150 participants or records.
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