Evaluation of the chemotherapeutic efficacy of moxifloxacin in experimental colibacteriosis of chickens
Abstract
The goal of the present study was to assess the chemotherapeutic effectiveness of moxifloxacin, at various doses, in experimental colibacillosis of chickens. Day-old Hisex Brown chickens were experimentally infected via intraperitoneal injection with Escherichia coli in suspension at a dose of 1.5 x 10^8 CFUs / 0.5 mL per chicken. For the sake of the experiment, we divided the chickens into 3 groups (n=90, in each group). The dose of moxifloxacin for Group I was determined 5 mg/kg body weight, Group II – 10 mg/kg body weight and Group III – 20 mg/kg body weight. In each group the chickens were challenged intraperitoneally once (ten chickens at a time), at 1h, 2h, 3h, 4h, 6h, 8h, 10h, 12h following the challenge and simultaneously with the challenge. The results of our research prove that the therapeutic effectiveness of moxifloxacin at a dose of 5 mg/kg body weight, in experimental colibacillosis, irrespective of the moment of administration of the drug in regard to the moment of the challenge, was insignificant. Moxifloxacin at the dose of 5 mg/kg body weight was just scarcely effective when it was administered to the chickens at 1h and 10h following the challenge and simultaneously with the challenge (total life span = 31 -39%). Otherwise, the specified dose of the drug proved ineffective. When the dose was increased to 10 mg/kg body weight the therapeutic effectiveness of the drug increased likewise. When moxifloxacin was administered to the chickens simultaneously with…
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.