The efficacy of autologous serum in corneal healing following metallic foreign body injuries
Abstract
Purpose: To evaluate the effect of topical autologous serum (AS) on corneal healing following metallic corneal foreign body (CFB) trauma.
Method: Following the removal of CFBs with a 26-gauge needle, patients were randomly divided into two groups. Group 1 patients received topical moxifloxacin and preservative- free artificial tears, while Group 2 participants used these drops in addition to AS five times a day. Patients were followed until their corneal epithelial defects were closed. The baseline size of the epithelial defects was measured, and corneal densitometry measurements using Pentacam HR (Oculus, Wetzlar, Germany) were obtained before treatment. Epithelial healing rates and post-treatment corneal densitometric measurements were compared.
Results: Group 1 comprised 41 male participants with a mean age of 36.1 ± 13.3 years, and Group 2 consisted of 42 male participants with a mean age of 34.9 ± 11.5 years. No statistically significant difference in age distribution was observed between the groups (p = 0.229). Complete epithelial closure occurred within 3.51 ± 1.03 days for Group 1 participants, whereas Group 2 participants achieved complete closure within 2.19 ± 1.10 days. A significantly faster rate of epithelial closure and a notably shorter duration were observed in Group 2 (p = 0.002 and p < 0.001, sincerely). Post-epithelial healing corneal densitometry measurements revealed significantly lower values in participants utilizing AS (p = 0.007).
Conclusion: The use…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 42 participants or records.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.