Prospective, randomized, contralateral eye comparison of wavefront-guided and topography-guided LASIK
Abstract
Purpose: To compare the visual outcomes of eyes treated with ocular wavefront-guided (OWFG) LASIK vs topography-guided (TG) LASIK.
Setting: Byers Eye Institute at Stanford University, Stanford, California.
Design: Prospective, randomized, contralateral eye-controlled trial. Treatments were randomized according to ocular dominance.
Methods: This study treated patients with myopia or compound myopic astigmatism with OWFG-LASIK (planned using the iDesign Advanced WaveScan Studio System aberrometer) in 1 eye and TG-LASIK (planned using the Contoura Vision and WaveLight Topolyzer Vario) in the fellow eye from January 2023 to April 2024. Postoperative evaluation was performed at 1, 3, 6, and 12 months postoperatively and consisted of visual acuity, manifest refraction, 5% and 25% low-contrast visual acuity, and higher-order aberrations (HOAs) (coma, trefoil, and spherical aberration).
Results: 100 eyes of 50 patients with myopia or compound myopic astigmatism were enrolled in the study and underwent successful treatments. 96 eyes of 48 patients completed 12 months of follow-up. At postoperative month 12, there were no statistically significant differences between the OWFG-LASIK and TG-LASIK groups for spherical equivalent ( P > .05); HOAs, including coma, trefoil, and spherical aberrations ( P > .05); proportion of eyes that had ≥20/20 uncorrected distance visual acuity (UDVA) (100% in the OWFG-LASIK group vs 98% in the TG-LASIK group); or proportion of eyes that had improved 5%…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 50 participants or records.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.