Effect of Empirical Treatment With Moxifloxacin and Meropenem vs Meropenem on Sepsis-Related Organ Dysfunction in Patients With Severe Sepsis: A Randomized Trial
Abstract
eMethods. Definitions of clinical and microbiological outcomes and protocol violations eFigure. Treatment effect of combination therapy on clinical outcome within various subgroups eTable 1. Antibiotics used one week prior to randomization eTable 2. Susceptibility patterns and numbers of resistant enrollment organisms eTable 3. Adverse events eTable 4. Response to therapy, clinical and microbiological cure eTable 5. Protocol violations
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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