Association between the atherogenic index of plasma and incident hypertension across different blood pressure states: a national cohort study
Abstract
Hypertension is a major public health concern, making effective preventive strategies essential. The atherogenic index of plasma (AIP), a new lipid metabolic index that is associated with insulin resistance and cardiovascular diseases. However, the association between AIP and the incidence of hypertension remains unexplored. To address this knowledge gap, we designed a large-scale retrospective cohort study to investigate the association between AIP and the occurrence of hypertension across different blood pressure (BP) states, including individuals with normal BP and those with elevated BP. This retrospective cohort study used data from the China Health and Retirement Longitudinal Study (CHARLS) involving participants aged 45 and older, assessed in 2011 and followed up in 2020. AIP was calculated using the logarithmic ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C). Logistic regression models, restricted cubic splines models, and threshold analyses were employed to examine the relationship between AIP and the incidence of hypertension. Receiver Operating Characteristic analysis was utilized to assess the ability of AIP to predict the incidence of hypertension. Subgroup analyses were conducted across various demographic and health-related factors. Sensitivity analyses were employed to address biases arising from self-reported data. Among 6540 participants, 1909 (29.19%) developed hypertension over nine years. The AIP is an independent risk factor…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 6,540 participants or records.
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