Association between the single-point insulin sensitivity estimator and cardiovascular disease incidence: A prospective nationwide cohort study involving two cohorts
Abstract
BACKGROUND
The single-point insulin sensitivity estimator (SPISE) index is a surrogate marker for insulin resistance. However, its association with cardiovascular disease (CVD) risk remains unclear.
METHODS
The study included 5755 participants from the Chinese Longitudinal Healthy Longevity Survey (CHARLS) and 2598 from the English Longitudinal Study of Ageing (ELSA). Cox proportional hazards models were used to examine the association between the SPISE index and CVD incidence, reporting hazard ratios (HR) and 95 % confidence intervals (CI). Within the Cox proportional hazards model framework, restricted cubic splines were applied to evaluate non-linear associations, and cumulative hazard curves were generated to illustrate the dynamics of risk over time. Subgroup analyses were conducted to assess effect heterogeneity, and a mediation analysis was performed to explore potential underlying mechanisms.
RESULTS
During the follow-up period (2004-2018 for ELSA and 2011-2018 for CHARLS), 935 (16.25 %) participants in CHARLS and 1026 (39.49 %) participants in ELSA developed CVD. In the fully adjusted Cox proportional hazards model, individuals in the highest tertile of the SPISE index had a significantly lower risk of CVD incidence compared with those in the lowest tertile (CHARLS: adjusted HR: 0.61, 95 % CI: 0.51-0.72; ELSA: adjusted HR: 0.83, 95 % CI: 0.71-0.98). RCS regression analysis showed a negative linear relationship between the SPISE index and the CVD incidence. A higher…
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.