Incidence of post-traumatic endophthalmitis following repaired open globe injury: impact of prophylactic intracameral moxifloxacin
Abstract
BACKGROUND/OBJECTIVES: To assess the effect of intracameral moxifloxacin (ICM) after repaired open globe injury (OGI) in reducing the incidence of post-traumatic endophthalmitis.
SUBJECTS/METHODS: Ambispective, consecutive, comparative study of patients operated of OGI repair. Patients were divided into two groups: those without intracameral antibiotic prophylaxis (No-ICM) (operated between 2002 and 2012) and those with ICM prophylaxis at the end of the procedure (ICM) (operated between 2013 and 2023). Both received standard povidone-iodine antisepsis. Endophthalmitis was defined as severe intraocular inflammation associated with hypopyon and/or vitritis.
RESULTS: 424 eyes (424 patients) were included, 294 in ICM group and 130 in No-ICM group. Male sex was 85.7% and 90.8% in ICM and No-ICM groups, respectively. The ICM group was significantly older than No-ICM group (median (IQR): 26 (14-41) vs. 21.5 (12-34), p = 0.025). The proportion of patients younger than 18 years was similar between ICM and No-ICM group (33.1% vs. 38.5%, p = 0.275). Post-traumatic endophthalmitis was significantly lower in ICM (2/294, 0.7%) compared to No-ICM (5/130, 3.9%) (p = 0.031) group. Sensitivity analysis age-adjusted confirmed the protective effect of ICM for endophthalmitis after OGI was independent of age (adjusted OR: 0.20; 95% CI: 0.04-0.86; p = 0.031). The relative risk of endophthalmitis with ICM compared with no-ICM was 0.18 (0.04-0.78), with relative risk reduction of 82%, absolute risk…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 424 participants or records.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.