Curated Cases from the TB Expert Network: Unplugged!: Navigating Uncertainty in Treatment of a Child with Multidrug-Resistant Tuberculosis
Abstract
The following case was presented as part of the Centers for Disease Control and Prevention Tuberculosis Centers of Excellence TB Expert Network: Unplugged! series. In September 2024, a panel of experts was convened to discuss a challenging pediatric case. The patient is an 11-year-old girl diagnosed with pulmonary multidrug resistant-TB (MDR-TB). At the heart of the discussion was consideration of the regimen of bedaquiline, pretomanid, and linezolid with or without moxifloxacin (BPaL/M) and how to extrapolate existing data from adult studies and navigate uncertainties with a child of this age. Prominent points of discussion included the lack of data and clinical experience with pre-tomanid, and whether and how delamanid might be incorporated into a regimen. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of
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