Rare Nocardia cyriacigeorgica osteomyelitis in an immunocompromised elderly patient: A case highlighting treatment challenges
Abstract
Nocardia cyriacigeorgica, an emerging pathogen, poses significant risks to immunocompromised patients. We report a rare case of N.cyriacigeorgica-induced osteomyelitis in an 82-year-old woman undergoing chemotherapy for relapsed follicular lymphoma. Her complex medical background included chronic kidney disease, heart failure, and recent skin infections. She presented with severe pain and swelling in a surgically replaced right knee. Initial evaluations, complicated by neutropenia and a necrotic lung lesion, suggested atypical infections. Despite broad-spectrum antibiotic therapy, the infection persisted. Synovial fluid analysis confirmed N.cyriacigeorgica, prompting surgical debridement and a modified antibiotic regimen. However, resistance issues and severe side effects complicated treatment, leading to a progressive decline in her condition. This case underscores the challenges of diagnosing and treating N.cyriacigeorgica infections, highlighting the need for enhanced diagnostic methods and personalized treatment approaches to manage resistance and complex patient profiles effectively.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.