Drug resistance of Mycoplasma genitalium: mechanism and regional distribution
Abstract
Mycoplasma genitalium is a significant sexually transmitted pathogen associated with various urogenital diseases and severe complications in both men and women. In recent years, advances in molecular diagnostic technologies have progressively revealed its global prevalence. Concurrently, the escalating issue of antibiotic resistance poses a major public health challenge. This review aims to summarize the clinical manifestations and resistance mechanisms of M. genitalium infection, the global epidemiological characteristics of antibiotic resistance, as well as the limitations and challenges of existing research, thereby providing a scientific basis for formulating effective control measures. Key acquired resistance mechanisms of M. genitalium include macrolide resistance due to 23S rRNA gene mutations; fluoroquinolone resistance triggered by parC and gyrA gene mutations; and tetracycline resistance associated with the mutations in the 16S rRNA gene. Major external drivers of resistance emergence and spread include antibiotic misuse, sexual transmission networks, latent transmission by asymptomatic carriers, and limitations in detection methods. In recent years, M. genitalium infections have been prevalent in many countries worldwide, with rising resistance rates observed in some regions. Resistance rates remain persistently high in Oceania, Asia, and parts of North America, while regions such as Africa exhibit relatively lower levels of resistance. The clinical management of…
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.