Systematic Review of Clinical Practice Guidelines for Post-Cataract Surgery Endophthalmitis Prophylaxis from 2008-2023
Abstract
Postoperative endophthalmitis remains a significant concern following cataract surgery with a potential for severe vision loss. Although numerous clinical practice guidelines (CPGs) have been published worldwide, they offer differing recommendations for prophylactic measures. This systematic review aimed to synthesize and evaluate existing guidelines for endophthalmitis prophylaxis after cataract surgery. A comprehensive search including citation and gray literature search was conducted. Authors' contact with peer international ophthalmologists was also employed. Clinical practice guidelines specifically on post-cataract surgery endophthalmitis prophylaxis published between 2008 and 2023 were included in this study. Quality assessment was done using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool. Twenty-one guidelines were identified, assessed, and extracted. Intracameral antibiotics, instillation of povidone-iodine into the conjunctival sac, and periorbital skin preparation with povidone-iodine were the most commonly endorsed measures, although recommended concentrations, dosages, and contact times varied. Several guidelines did not address ancillary measures, such as face washing, postoperative eye protection or adjunctive topical antibiotics. While core prophylactic strategies were broadly agreed upon, significant differences persisted likely due to disparate local regulations, idiosyncratic practices, and interpretations of the evidence.…
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.