Effects of fluoroquinolone on mitral and aortic regurgitation: A systematic review and meta-analysis
Abstract
This study aimed to systematically review and meta-analyze the effects of fluoroquinolones on mitral and aortic regurgitation. Seven electronic databases were searched for relevant research data published in English and Thai between the database’s inception and September 30, 2022, including additional records from Silpakorn University and Chulalongkorn University’s online theses databases. This systematic review included studies that compared the effects of fluoroquinolones and other antibiotic classes on the occurrence of mitral and aortic valve regurgitation. Subsequently, the quality of the research was evaluated using the Newcastle-Ottawa Quality Assessment Scale. Of the 2,891 articles identified, two eligible studies were included in the analysis. The meta-analysis examined different exposure periods and discovered that individuals who received fluoroquinolones within 30 days and within one year had a similar risk of developing mitral and aortic valve regurgitation compared to those who received other groups of antibiotics. Specifically, the risk of mitral and aortic regurgitation associated with fluoroquinolones was comparable to that of amoxicillin and macrolides. Overall, the meta-analysis found no association between fluoroquinolone use and the development of mitral and aortic regurgitation.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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