Effectiveness of Different Treatment Regimens for Patients with Newly Diagnosed Pulmonary Tuberculosis Susceptible to Antituberculosis Drugs
Abstract
Development of new, more effective methods of tuberculosis treatment is one of the priority areas of modern phthisiology. In recent years, antibacterial drugs of the fluoroquinolone series have begun to be widely used in the treatment of not only resistant, but also drug-susceptible tuberculosis.
Objective — to evaluate the effectiveness of a 4-month chemotherapy regimen for newly diagnosed sensitive pulmonary tuberculosis, which includes moxifloxacin and rifapentine.
Materials and methods. To achieve the goal, 65 patients with newly diagnosed drug-susceptible pulmonary tuberculosis were selected. 33 patients (main group) were treated with a 4-month regimen that included moxifloxacin and rifapentine in the intensive and continuation phases of treatment: 2HPZMfx 2HPMfx. 32 patients in the control group were treated with a standard 6-month regimen: 2HREZ 4HR. The average age of patients in the main group was 45.3 ± 1.3, in the control group — (44.8 ± 1.2; p > 0.05) years, in both groups people from 35 to 55 years prevailed. There were 24 men in the main group (72.73 %), 9 women (27.27 %), respectively in the control group — 23 (71.88 %) and 9 (28.12 %). Patients in both groups were identical in age, sex, clinical forms of pulmonary tuberculosis, the presence of bacterial excretion and comorbid conditions.
Results and discussion. Analysis of the data obtained showed that the cessation of bacterial excretion occurred in all (33; 100 %) patients in the main group and in 30 (93.75…
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.