Emergency management and nursing care of a patient with moxifloxacin-induced anaphylactic shock complicated with Takotsubo syndrome
Abstract
Abstract Background Takotsubo syndrome (TTS) is an acute cardiac condition marked by reversible left ventricular dysfunction, with clinical features that resemble acute coronary syndrome but occur without significant coronary artery stenosis. Its development is strongly linked to catecholamine-mediated toxicity. Inflammatory mediators released during allergic responses may further amplify catecholamine secretion; however, drug-induced anaphylactic shock accompanied by TTS has only been rarely documented. Case Presentation A 31-year-old female experienced simultaneous anaphylactic shock and TTS (EF 31%) after receiving intravenous moxifloxacin. Emergency management involved adrenaline, corticosteroids, and antihistamines, together with PICCO-guided circulatory support (target MAP ≥ 65 mmHg) and combined antiplatelet/anticoagulant therapy. A family-based “3-min emergency response” training program and a graded rehabilitation protocol were carried out. Before discharge, ADRB1 genetic testing was completed, which identified the GG genotype, and beta-blocker treatment was then started accordingly. The patient’s EF increased to 45% within 48 h, recovered completely within 10 days, and remained stable throughout 6-month pregnancy follow-up under multidisciplinary care, including dynamic EF monitoring ≥ 55% and anticoagulant adjustment. Conclusion Moxifloxacin may contribute to TTS through allergic-sympathetic pathways, making careful recognition of overlapping symptoms necessary.…
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.