Simvastatin and Moxifloxacin Co-Delivery via ZIF-8/PDA Coating on PEEK Implants: A Strategy for Combating Implant-Associated Infection and Enhancing Osseointegration
Abstract
Zidong Wu,1,* Kai Ma,1,2,* Zixuan Wu,1,* Xiaoyu Guo,1 Yuning Qu,1 Zheyue Zhu,1 Weidong Zhu,1,3 Chengxin Li,2 Yi Liu,1,2 Rui Ma,1 Pei Yang1 1Joint and Foot & Ankle Ward of Orthopedic Center, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710004, People’s Republic of China; 2State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an, 710049, People’s Republic of China; 3Department of Spinal Surgery, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Rui Ma; Pei Yang, Email [email protected]; [email protected]: Polyetheretherketone (PEEK) is a promising orthopedic implant material due to its bone-matched elastic modulus and radiolucency. However, its clinical application is limited by biological inertness and lack of antibacterial activity, which predispose to implant-associated infection (IAI) and poor osseointegration. This study developed a multifunctional coating on sulfonated PEEK (SPEEK) via polydopamine (PDA)-mediated co-delivery of simvastatin-loaded ZIF-8 nanoparticles (SIM@ZIF-8) and moxifloxacin (MOX) to address these limitations.Methods: A time-programmed release coating was fabricated on SPEEK by embedding SIM@ZIF-8 within a PDA layer and surface-loading MOX onto the surface. The coating’s physicochemical properties, drug release profiles,…
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