Exploration of Nanoparticulate Sol-Gel System of Moxifloxacin Hydrochloride in Ophthalmic Delivery
Abstract
Moxifloxacin hydrochloride, an ophthalmic solution, treats bacterial eye infections but suffers from rapid lachrymal drainage and poor corneal penetration. This study aims to enhance corneal penetration by combining nanoparticles with an in-situ gelling system. Chitosan nanoparticles were synthesized using the ionotropic gelation method, guided by a 'Custom experimental design' approach. Key parameters, including drug entrapment efficiency, particle size, and drug release profiles, were evaluated, and the model's fit was analyzed using ANOVA. Characterization of the formulations included particle size analysis, SEM, DSC, and FTIR. Sodium alginate nanoparticle gels were analyzed for gelling capacity, viscosity, and drug diffusion and permeation studies. Sixteen formulations were created, with drug entrapment efficiency ranging from 70.9 ± 0.08% to 89.7 ± 0.09% and diffusion profiles between 67.3 ± 0.03% and 90.6 ± 0.08%. The most influential formulation had an average particle size of 497nm, and SEM revealed slightly agglomerated particles with uneven surfaces. This formulation exhibited a onefold increase in permeability coefficient and a twofold increase from the nanoparticulate in situ gel compared to marketed drops (0.5% w/v) and the pure drug in situ gel, indicating its potential to penetrate deeper eye layers. The eye irritation study reports no irritation. The developed formulation also showed enhanced antimicrobial activity against E. coli and S. aureus compared to…
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