Comparative evaluation of antimicrobial properties of calcium hydroxide-loaded polylactic-co-glycolic acid nanoparticles and calcium hydroxide: A systematic review and meta-analysis
Abstract
Aim: The aim of the study was to evaluate the antimicrobial properties of calcium hydroxide (CH)-loaded polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) and CH when used as an intracanal medicament (ICM).
Methods: Adhering guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis, the review was registered in the Prospective Registration of Systematic Review-CRD42023454265. Databases from January 2000 to December 2023 were examined for studies evaluating the various properties of CH-loaded PLGA NPs compared to conventional ICM-CH. Using the Cochrane risk of bias (ROB)-2 tool for randomized clinical trials (RCTs) through its domains using Review Manager (RevMan) software version 5.3, quality assessment was evaluated. Standardized mean difference (SMD) was used as a summary statistic measure with a random effect model (P < 0.05).
Results: To fulfill eligibility criteria, six studies were included in qualitative synthesis, from which three were fit for meta-analysis. The quality assessment revealed a moderate to low ROB. The pooled estimate through SMD (0.45 [-1.17-0.27]) and the favored intervention group (CH-loaded PLGA NPs) showed that the reduction in smear layer/biofilm was more significant in the intervention group. Indicating the absence of publication bias, no presence of any heterogeneity was revealed by the funnel plot.
Conclusion: It was observed that CH-loaded PLGA NPs showed improved antibacterial properties, greater dentinal tubule…
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Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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