Moxifloxacin Hydrochloride Loaded Proliposomal Gel: Formulation, Characterization and Therapeutic Evaluation of Periodontitis
Abstract
Periodontitis is a chronic inflammatory disease leading to progressive destruction of periodontal tissues. This study presents the formulation and evaluation of a Moxifloxacin hydrochloride (MH)-loaded proliposomal gel designed for sustained localized delivery to periodontal sites. MH-loaded proliposomes were fabricated by the film dispersion freeze-drying technique and optimized using a response surface design to achieve high entrapment efficiency and controlled particle size. The entrapment efficiency ranged from 70.1% to 91.4%; batch PL4 showed the highest MH entrapment. The optimized formulation exhibited an average particle size of 215.2 nm, a PDI of 0.139, and a zeta potential of − 21.7 mV, confirming colloidal stability. Transmission electron microscopy revealed spherical bilayered vesicles. Incorporation of proliposomes into a Carbopol® 934P gel yielded a bioadhesive matrix with optimal viscosity, pH compatibility, and uniform drug distribution. In-vitro studies demonstrated sustained MH release over 12 h, following Higuchi kinetics, whereas ex-vivo permeation across porcine buccal mucosa showed an increase in flux compared with the conventional gel. The optimized formulation (PLG8) exhibited significant antibacterial activity against Staphylococcus aureus and Escherichia coli, with no irritation in the HET-CAM assay, confirming its biocompatibility. Stability analysis over six months verified physicochemical integrity under ICH conditions. These findings suggest…
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.