Formulation, Development and Evaluation of Taste-Masked Moxifloxacin Hydrochloride Oral Dry Suspension Using Electronic Tongue
Abstract
The intensely bitter taste of several orally administered drugs represents a major challenge in the development of acceptable pediatric and geriatric formulations. Moxifloxacin hydrochloride, a broad-spectrum fluoroquinolone antibacterial agent, possesses an unpleasant bitter taste that may adversely affect medication acceptance and adherence, particularly when administered as a liquid dosage form. The present investigation was undertaken to formulate, optimize, and evaluate a taste-masked oral dry suspension of Moxifloxacin hydrochloride using ion-exchange resin complexation, with objective assessment of taste masking by an Electronic Tongue (e-Tongue). Drug–resin complexes were prepared by the batch ion-exchange method using Tulsion® 339, Tulsion® 344, Tulsion® 335, and Indion® 414 at drug-to-resin ratios of 1:1, 1:2, and 1:3 (w/w). The effects of drug–resin ratio, pH, and stirring speed on drug loading were investigated. The prepared resinates were characterized for appearance, pH, solubility, particle size, micromeritic properties, Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscopy (SEM). In-vitro drug release was studied under simulated salivary and gastrointestinal conditions. Taste-masking performance was objectively assessed using an Electronic Tongue and multivariate pattern analysis. The optimized resinate was subsequently incorporated into a reconstitutable oral dry…
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