Protein and drug designing of nocardia by using in silico approach
Abstract
Nocardia asteroides , is a saprophytic, filamentous aerobic, Gram-positive and mycolic acid cell wall bacteria that is responsible for Nocardiosis, which is a chronic bacterial disease of humans and many other animals originating in the respiratory tract and disseminated by way of blood to other organs.It is caused by either introduction of the species into the skin or by inhalation of the species from its habitat.In the present study, we have identified a set of potential drug targets in the Nocardiosis-causing bacterium, Nocardia asteroides, by performing in-silico subtractive genomic approach.The bacterial enzymes which bear no significant similarity to human proteins were identified using a BLASTp search Presence of homologs in the prokaryotic database of essential genes suggests that an enzyme could be essential for survival of the pathogen, and hence was taken as a criterion for short listing the potential drug targets in Nocardia asteroides.After that, proteins were searched for their metabolic pathway using KEGG database.
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