Efficacy and Safety of Silodosin, Mirabegron, and Tadalafil as a Medical Expulsive Therapy for Lower Ureteric Stones: A Prospective, Randomized, Comparative Study
Abstract
Purpose: We aim to evaluate and compare the efficacy and safety of silodosin, mirabegron, and tadalafil as a medicalexpulsive therapy (MET) for lower ureteric stones in adults.Material and methods: A total of 150 cases who had unilateral, single, lower ureteric stone between December 2021 andAugust 2022 were incorporated in this prospective, randomized comparative study. The patients were randomly dividedinto three equal groups. The first group received Silodosin, the second group received mirabegron, and the third groupreceived tadalafil. The medications would be continued until expulsion of the stone, for a maximum of 3 weeks. Theduration of medical therapy for each patient was no longer than 3 weeks. The treatment duration was until stoneexpulsion or 3 weeks, whichever came first. The success was considered if the stone passed during 3 weeks of thetreatment, if the stone did not pass during the 3 weeks that was considered as a failure, and the patient underwentureteroscopic intervention for stone removal.Results: Altogether 150 patients 50 (33.3%) in group 1 (Silodosin group), 50 (33.3%) in group 2 (mirabegron group), and50 (33.3%) in group 3 (Tadalafil group) were enrolled in the study. Expulsion rates for groups 1, 2, and 3 were 86%, 72%,and 78%, respectively; however, no significant difference (P value > 0.05) was determined.Conclusion: While none was noticeably better than the others, silodosin, mirabegron, and tadalafil showed increasedexpulsion rates for distal…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 150 participants or records.
Read the paper
Related studies
- Safety and efficacy of COVID‐19 vaccines: A systematic review and meta‐analysis of controlled and randomized clinical trials
- Accuracy Comparison between Robot-Assisted Dental Implant Placement and Static/Dynamic Computer-Assisted Implant Surgery: A Systematic Review and Meta-Analysis of In Vitro Studies
- Determinants of passive antibody efficacy in SARS-CoV-2 infection: a systematic review and meta-analysis
- Cleaning efficacy of EDDY versus ultrasonically-activated irrigation in root canals: a systematic review and meta-analysis
- Bonding Efficacy of Universal Resin Adhesives to Zirconia Substrates: Systematic Review and Meta-Analysis
- In vitro antimicrobial activity of extracts and essential oils of Cinnamomum, Salvia, and Mentha spp. against foodborne pathogens: A meta-analysis study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.