Efficacy, Safety and Tolerability of Lisdexamfetamine Dimesylate Treatment Compared With Placebo in Adults With Binge-Eating Disorder: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Abstract
INTRODUCTION
Binge-Eating Disorder (BED) causes significant psychosocial impairment and comorbidities like obesity, depression, and anxiety. Given the limited effectiveness of current treatments, Lisdexamfetamine dimesylate (LDX), approved for Attention-Deficit/Hyperactivity Disorder- ADHD and BED in the U.S., may provide a promising alternative by enhancing impulse control and targeting reward pathways.
OBJECTIVE
This study aims to assess the efficacy, safety, and tolerability of LDX compared with placebo in adults with BED.
METHODS
We systematically searched PubMed, Embase and Cochrane databates for randomised controlled trials (RCTs). We used a random-effects model with a 95% confidence interval (CI) to pool the data. Outcomes analysed included binge-eating frequency, Yale-Brown Obsessive-Compulsive Scale for Binge-Eating (Y-BOCS-BE), weight change, treatment-emergent adverse events (TEAEs), and discontinuation rates. Sensitivity analyses were performed to assess heterogeneity. This systematic review and meta-analysis was prospectively registered in PROSPERO (CRD42024619617).
RESULTS
Five RCTs were included in this meta-analysis, encompassing a total of 988 participants. LDX significantly reduced binge-eating days per week by an average of 1.29 days and decreased obsessive-compulsive behaviours by 6.16 points on the Y-BOCS-BE scale, compared with placebo. Additionally, LDX led to a significant weight reduction with an average decrease of 1.31 standardised mean differences…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 988 participants or records.
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