Efficacy of neurosurgical intervention in syrinx resolution in patients presenting with Chiari malformation type I and syringomyelia: a systematic review and radiological meta-analysis
Abstract
Neurosurgical techniques have been used to treat Chiari Malformation type 1 (CM1). However, there remains some uncertainty regarding which neurosurgical procedure is most efficacious in treating patients with CMI and syringomyelia. Our study aims to compare the efficacy of available neurosurgical techniques in resolving syrinx for patients with CM1 and syringomyelia. Included studies must report both pre-and post-operative syrinx measurements, discuss the use of nurosurgery, and involve patients with CM1 and syringomyelia. Studies with less than 5 patients were excluded. Databases used to identify studies included PubMed, Scopus, Cochrane Library, Web of Science, and Ovid. The Newcastle-Ottawa Scale, Joanna Briggs Institute checklist, and the Risk of Bias 2 analysis tools assesed the risk of bias in the study. A meta-analysis was conducted using a random-effects model, and forest plots illustrated the results. A total of 20 studies involving 3,063 patients with CM1 and syringomyelia were included in the study. Posterior fossa decompression with duraplasty (PFDD) demonstrated significant syrinx reduction: syrinx width (SW) reduced by a mean difference (MD) of 2.46 mm (95% CI: 2.16–2.76), syrinx length by 1.68 vertebral segments (95% CI: 1.44–1.92), and syrinx-to-cord ratio by 0.21( 95% CI: 0.15 to 0.26). Posterior fossa decompression with tonsillar reduction (PFDTR) had significantly reduced SW (MD: 2.85 mm, 95% CI: 1.99–3.71). It was superior to PFDD in the syrinx-to-cord…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 3,063 participants or records.
Read the paper
Related studies
- Safety and efficacy of COVID‐19 vaccines: A systematic review and meta‐analysis of controlled and randomized clinical trials
- Accuracy Comparison between Robot-Assisted Dental Implant Placement and Static/Dynamic Computer-Assisted Implant Surgery: A Systematic Review and Meta-Analysis of In Vitro Studies
- Determinants of passive antibody efficacy in SARS-CoV-2 infection: a systematic review and meta-analysis
- Cleaning efficacy of EDDY versus ultrasonically-activated irrigation in root canals: a systematic review and meta-analysis
- Bonding Efficacy of Universal Resin Adhesives to Zirconia Substrates: Systematic Review and Meta-Analysis
- In vitro antimicrobial activity of extracts and essential oils of Cinnamomum, Salvia, and Mentha spp. against foodborne pathogens: A meta-analysis study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.