First Report of Trametinib‐Nintedanib Combination in KRAS G12D‐Mutated Pancreatic Cancer: Efficacy and Fatal Hemorrhagic Complication: A Case Report
Abstract
This is the first report of trametinib‐nintedanib for a 57‐year‐old KRAS G12D‐mutated recurrent pancreatic ductal adenocarcinoma. He had transient remission (lower CA19‐9, stable lesions) but died of gastrointestinal bleeding, showing efficacy and bleeding risk.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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