Splenic artery embolization for the treatment of spontaneous splenic rupture in hemophilia A: a case report
Abstract
Background Hemophilia is an X-linked recessive inherited bleeding disorder caused by genetic defects in specific proteins involved in blood coagulation. It is classified into two main types: hemophilia A and hemophilia B. The primary clinical characteristic of hemophilia is prolonged spontaneous and/or traumatic bleeding, which most commonly occurs within the musculoskeletal system. However, spontaneous splenic rupture in adults with hemophilia A has been reported infrequently. This rare but life-threatening condition necessitates prompt diagnosis and intervention. This study aims to evaluate the safety and efficacy of splenic artery embolization (SAE) in patients with hemophilia A who present with spontaneous splenic rupture and maintain hemodynamic stability. Case Description This case report describes a 20-year-old male with hemophilia A [factor VIII (FVIII) activity at 5%] who presented with intermittent epigastric distension and discomfort with a 3-day history. Imaging studies confirmed the presence of splenic rupture with hemoperitoneum. Emergency SAE was performed, successfully achieving hemostasis. Both preoperatively and postoperatively, the patient received FVIII replacement therapy along with other blood products. As a result, the patient’s FVIII level increased to 31%, hemoglobin stabilized at 100 g/L, and the patient was discharged after 1 week. Conclusions This case underscores the efficacy of SAE as a minimally invasive and effective treatment for spontaneous…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Safety and efficacy of COVID‐19 vaccines: A systematic review and meta‐analysis of controlled and randomized clinical trials
- Accuracy Comparison between Robot-Assisted Dental Implant Placement and Static/Dynamic Computer-Assisted Implant Surgery: A Systematic Review and Meta-Analysis of In Vitro Studies
- Determinants of passive antibody efficacy in SARS-CoV-2 infection: a systematic review and meta-analysis
- Cleaning efficacy of EDDY versus ultrasonically-activated irrigation in root canals: a systematic review and meta-analysis
- Bonding Efficacy of Universal Resin Adhesives to Zirconia Substrates: Systematic Review and Meta-Analysis
- In vitro antimicrobial activity of extracts and essential oils of Cinnamomum, Salvia, and Mentha spp. against foodborne pathogens: A meta-analysis study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.