Efficacy and Safety of Sotatercept in Pulmonary Arterial Hypertension: A Systematic Review
Abstract
Context: Pulmonary arterial hypertension (PAH) is characterized by the narrowing and remodeling of small pulmonary arteries, resulting from an imbalance in signaling pathways that regulate cell proliferation. Current therapeutic strategies for PAH target specific pathways to enhance pulmonary hemodynamics, including soluble guanylate cyclase stimulators, endothelin receptor antagonists, and prostacyclin pathway modulators. Sotatercept emerges as a promising therapeutic option that targets the underlying mechanism of PAH by improving the integrity of the endothelial layer of pulmonary arteries, promoting cellular proliferation, and alleviating vascular dysfunction. Objectives: This study systematically aims to review existing literature on the efficacy and safety of sotatercept in treating PAH. Methods: A comprehensive search was conducted across five online databases (PubMed, Scopus, Web of Science, Embase, and Google Scholar) to identify relevant studies. Original studies with human participants that investigated the efficacy and safety of sotatercept in patients with PAH were included. The primary outcomes assessed included clinical parameters such as pulmonary artery wedge pressure (PAWP), pulmonary vascular resistance (PVR), mean right atrial pressure (mRAP), mean pulmonary artery pressure (mPAP), 6-minute walk distance (6MWD), and improvements in World Health Organization functional class (WHO FC) over follow-up periods of up to 24 weeks. Additionally, adverse events…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 323 participants or records.
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