Comparative efficacy of PDE-5 inhibitor monotherapy and combination therapy with rhythmic peripheral magnetic stimulation in patients with erectile dysfunction and premature ejaculation
Abstract
Introduction. The combination of erectile dysfunction (ED) and premature ejaculation (PE) requires an integrated therapeutic approach.
Purpose of study. Compare the efficacy of tadalafil monotherapy and combination therapy with rhythmic peripheral magnetic stimulation (rPMS).
Materials and methods. A prospective randomized study included 29 patients with ED and PE, divided into two groups: Group 1 (n=14) received tadalafil 5 mg/day, while Group 2 (n=15) received tadalafil 5 mg/day combined with rPMS (15 sessions). Efficacy was evaluated after 6 weeks based on changes in the International Index of Erectile Function (IIEF-5), Premature Ejaculation Diagnostic Tool (PEDT), intravaginal ejaculatory latency time (IELT), and subjective visual analog scale (VAS) scores for patient (VAS 1) and partner (VAS 2) satisfaction.
Results. Group 2 demonstrated significantly greater improvement across all parameters: ΔIIEF-5 +10.4±1.4 vs. +5.4±1.1 (p<0.001), ΔPEDT -5.0±0.9 vs. -2.0±0.8 (p<0.001), and ΔIELT +104.6±8.5 sec vs. +36.2±6.8 sec (p<0.001). Partner satisfaction increased by 4.07±3.27 points in Group 2 compared to 3.33±2.99 in Group 1 (p<0.001).
Conclusion. The obtained data indicate a more pronounced positive change in the main clinical parameters in the combination therapy group. Improvements in IIEF-5 and PEDT scores, an increase in IELT, as well as greater subjective satisfaction among both patients and their partners, allow rhythmic peripheral magnetic stimulation (rPMS) to be…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 29 participants or records.
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