Efficacy of Lycopene Extracted from Tomato on Liver Enzymes and Tissues of Animal Model Infected with Acrylamide
Abstract
Lycopene is a carotenoid derivative, which is a natural pigment synthesized by plants and microorganisms during the photosynthesis process. The study aimed to extract lycopene from tomatoes using organic solvents in a ratio of 2:1:1 of hexane, acetone, and ethanol. The amount of lycopene extracted was (4.87 mg/100 g). We notice a decrease in the values of the liver enzymes ALT, ALK, and AST upon oral administration of lycopene to male infected rats compared to with their values when acrylamide is given alone. A change was also noted in the liver tissue after treatment with lycopene compared to the infected group, as there was an improvement in the central vein, lobules, hepatic sinusoids, and Coover cells after they were congested, expanded, and contained bloody bleeding. In conclusion, lycopene as an antioxidant phyto-component, can protect liver against damages caused by acrylamide (or acrylic amide). Tomatoes can be considering as functional vegetable for protecting liver from damages of chemicals such as acrylamide.
Keywords: Acrylamide, lycopene extraction, physiological properties, phytocomponent.
Read the paper
Related studies
- Safety and efficacy of COVID‐19 vaccines: A systematic review and meta‐analysis of controlled and randomized clinical trials
- Accuracy Comparison between Robot-Assisted Dental Implant Placement and Static/Dynamic Computer-Assisted Implant Surgery: A Systematic Review and Meta-Analysis of In Vitro Studies
- Determinants of passive antibody efficacy in SARS-CoV-2 infection: a systematic review and meta-analysis
- Cleaning efficacy of EDDY versus ultrasonically-activated irrigation in root canals: a systematic review and meta-analysis
- Bonding Efficacy of Universal Resin Adhesives to Zirconia Substrates: Systematic Review and Meta-Analysis
- In vitro antimicrobial activity of extracts and essential oils of Cinnamomum, Salvia, and Mentha spp. against foodborne pathogens: A meta-analysis study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.