Green synthesis of propolis mediated silver nanoparticles with antioxidant, antibacterial, anti-inflammatory properties and their burn wound healing efficacy in animal model
Abstract
Developing an efficient and cost-effective wound-healing substance to treat wounds and regenerate skin is desperately needed in the current world. The present study evaluated in vivo wound healing and in vitro antioxidant, antibacterial, anti-inflammatory activities of propolis mediated silver nanoparticles. Extract of Bee propolis from northeast Punjab, Pakistan, has been prepared via maceration and subjected to chemical identification. The results revealed that it is rich in phenolic contents (88 ± 0.004 mg GAE ml−1, 34 ± 0.1875 mg QE ml−1) hence, employed as a reducer and capping agent to afford silver nanoparticles (AgNPs) by green approach. The prepared nanoparticles have been characterized by UV-visible (UV–vis), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), x-ray diffraction (XRD). The propolis mediated AgNPs possess cubic face center with spherical shape and measured 50–60 nm in size. Moreover, propolis mediated silver nanoparticles have been studied for various biological activities. The results showed excellent antioxidant (0.4696 μg ml−1), anti-inflammatory (0.3996 μg ml−1) and antibacterial activities against Staphylococcus aureus (MIC 0.462 μg ml−1) and Proteus mirabilis (MIC 0.659 μg ml−1) bacterium. An ointment was prepared by mixing AgNPs with polymeric gels for burn wound treatment in rabbits. We found rapid wound healing and higher collagen deposition in AgNPs treated wounds than in control group. Our data suggest that…
Read the paper
Related studies
- Safety and efficacy of COVID‐19 vaccines: A systematic review and meta‐analysis of controlled and randomized clinical trials
- Accuracy Comparison between Robot-Assisted Dental Implant Placement and Static/Dynamic Computer-Assisted Implant Surgery: A Systematic Review and Meta-Analysis of In Vitro Studies
- Determinants of passive antibody efficacy in SARS-CoV-2 infection: a systematic review and meta-analysis
- Cleaning efficacy of EDDY versus ultrasonically-activated irrigation in root canals: a systematic review and meta-analysis
- Bonding Efficacy of Universal Resin Adhesives to Zirconia Substrates: Systematic Review and Meta-Analysis
- In vitro antimicrobial activity of extracts and essential oils of Cinnamomum, Salvia, and Mentha spp. against foodborne pathogens: A meta-analysis study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.