Bioplastic Food Packaging and the Young Women’s Exposome: Body Burden of Bisphenols in a Randomized Intervention Trial
Abstract
Abstract Bisphenol A (BPA) and bisphenol F (BPF) are widely used in the manufacturing of plastics, food-contact materials, and a range of consumer products, including personal care, hygiene and cosmetics. Bisphenols are ubiquitously detected in human biospecimens, yet the relative contribution of multiple exposure sources and routes of human exposure to their body burden remain poorly understood. We conducted a randomized crossover trial among 39 healthy women aged 18–40 years to investigate whether replacing conventional food packaging with biopolymer-based alternatives (easily biodegradable and void of bisphenols) would reduce the body burden of bisphenols. Participants completed two five-day study periods (conventional and bioplastic food packaging) and collected repeated urine samples and diaries capturing 30 food-packaging, personal care, and cosmetics types of plastics-associated exposures. Traditional mixed-effect models of bisphenols evaluated intervention treatment effectiveness, while an alternative approach deployed an exposomic-driven analytical pipeline comprising of exposome-wide association analyses (ExWAS), LASSO regression, and latent class analysis to screen, select and potentially identify intervention-induced exposomic signatures of lower burden of bisphenols. Latent class analysis identified two distinct plastics-associated profiles. Cluster 1 represented a low-plastics multi-source exposomic profile, characterized by low probabilities of cosmetics and…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 39 participants or records.
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