Targeted Data Fusion for Region-Specific Survival Effects in the AMP HIV Prevention Trials
Abstract
The Antibody Mediated Prevention (AMP) trials opened a new scientific frontier by showing that passively administered monoclonal broadly neutralizing antibodies (bnAbs) could prevent HIV-1 acquisition. Conducted across multiple geographic regions, including the United States, Brazil, Peru, Switzerland, and sub-Saharan Africa, the AMP trials revealed substantial regional heterogeneity in treatment efficacy. These differences, together with privacy and regulatory limits on central data pooling, call for methods that borrow strength across regions without sharing individual-level data. To estimate region- and treatment-specific survival curves under distributional heterogeneity, we develop a federated learning approach that combines site-specific estimators via an L1-regularized criterion that downweights data sources not aligned with the target. We further extend the framework to a general class of causal contrasts, including the risk difference (RD), survival ratio (SR), and restricted mean survival time (RMST) difference. Through extensive simulations and an analysis of the AMP trials under different target populations, we show that the proposed approach provides privacy-preserving, region-adaptive inference with improved precision.
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