Exploring the Relationship Between Berberine and the Gut Microbiome: A Closer Look at Recent Studies
Abstract
Objective: Berberine, a bioactive compound, has many health-promoting properties such as blood glucose regulation, anti-inflammatory effects and antimicrobial properties. Recent studies have shown that berberine increases the diversity of the gut microbiota, alters microbial communities and can repair damaged microbial profiles, but reviews of the impact of this relationship, particularly on disease, have been limited. Therefore, we aimed to evaluate the effect of berberine on microbiota diversity and composition through diseases.
Methods: An extensive search in electronic databases (PubMed, Web of Sciences, Science Direct, Google Scholar) was used to evaluate microbial changes resulting from the interaction of berberine and gut microbiota. A detailed evaluation was performed, pre-screening 84 titles and abstracts and assessing 51 full texts against the inclusion criteria.
Results: Berberine, encourage the growth of beneficial species like Bacteroidetes and Akkermansia, targeting specific pathogens and displaying antimicrobial properties. Studies, especially with obese or Type 2 Diabetic mice, indicate potential benefits in improving gut microbiota and diversity. The lack of a defined optimal dosage and unassessed individual microbial responses has also been linked to the formation of dysbiotic microbiota profiles.
Conclusion: The perceptible link between berberine and its positive impact on health underscores the significance of its interaction with the gut microbiota.…
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