Harmonizing Indian Traditional Medicine with Advanced Cancer Immunotherapy: A Fusion of Ancient Wisdom and Modern Innovation
Abstract
The convergence of Indian traditional medicine and advanced cancer immunotherapy represents a promising interdisciplinary frontier in oncology. Traditional systems such as Ayurveda and Siddha emphasize holistic healing through herbal formulations, dietary interventions, and lifestyle modifications aimed at restoring immune balance. These approaches align well with contemporary immunotherapeutic strategies, including immune checkpoint inhibitors, CAR-T cell therapy, monoclonal antibodies, and gene-editing technologies. Integrating traditional knowledge with modern immunotherapy could enhance treatment efficacy, minimize adverse effects, and improve patient quality of life. Natural compounds such as curcumin, berberine, and ashwagandha have demonstrated immunomodulatory and anti-cancer properties, showing potential as complementary agents. Furthermore, emerging evidence underscores the pivotal role of the gut microbiome in cancer progression and therapeutic response, with fecal microbiota transplantation (FMT), probiotics, and dietbased interventions showing clinical promise. This review consolidates historical perspectives, therapeutic advances, microbiome-cancer interactions, and the role of bioactive herbal compounds in immunomodulation, highlighting their synergistic potential in shaping next-generation cancer therapies. By bridging ancient wisdom with cutting-edge biomedical innovation, a more personalized, sustainable, and integrative paradigm for cancer care may be…
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