Influence of gut microbiome composition on treatment efficacy and toxicity in bladder cancer: A comprehensive meta-analysis
Abstract
768
Background:
The gut microbiome has emerged as a critical factor influencing the efficacy and toxicity of cancer treatments. In bladder cancer, variations in microbiome composition may affect patient responses to therapy, including immunotherapy and chemotherapy. This meta-analysis aims to comprehensively evaluate the impact of gut microbiome composition on treatment outcomes in bladder cancer.
Methods:
The PubMed, Embase, Scopus and Cochrane databases were systematically searched from inception until June 2024 using relevant keywords. The pooled data were presented as Odds Ratio (OR) with 95% confidence intervals (CI) using Random Effects model in OpenMeta (version 5.3). The I
2
and X
2
statistics were used to evaluate inter-study heterogeneity. An I
2
value of >50% was considered significant heterogeneity. The subgroup analyses were conducted to identify specific microbiome profiles associated with different treatment responses.
Results:
A total of 20 studies comprising 2,500 bladder cancer patients were included in the meta-analysis. Patients with a higher abundance of beneficial bacteria such as
Bifidobacterium
and
Lactobacillus
had significantly better treatment responses (OR: 2.5, 95% CI: 1.8-3.4) and lower toxicity rates (OR: 0.6, 95% CI: 0.4-0.9). Conversely, an increased presence of pathogenic bacteria like
Clostridium
and
Escherichia coli
was associated with poorer outcomes (OR: 0.5, 95% CI: 0.3-0.8) and higher toxicity (OR: 1.9, 95% CI: 1.3-2.7).
Conclusions:…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 2,500 participants or records.
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