Comment on “Gut microbiome changes associated with chronic pancreatitis and pancreatic cancer: a systematic review and meta-analysis”
Abstract
Chronic pancreatitis (CP) is characterized by the development of parenchyma fibrosis and ongoing pancreatic inflammation [ 1 , 2 ] . Chronic inflammation in the endocrine and exocrine pancreatic tissues results in ongoing, segmental, irreversible regional, or systemic damage. Clinical signs of CP patients may include epi-gastric discomfort, acute pancreatitis, diabetes mellitus, as well as pancreatic exocrine dysfunction, all of which are caused by progressive damage to the pancreas. In severe cases, about 5% of CP patients may develop pancreatic cancer, which has a poor prognosis and is one of the main risk factors for the disease. Gut microbiota
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