Influence of Gut Microbiome Composition on Surgical Site Infections: A Systematic Review and Meta-analysis
Abstract
Post-operative wound infections are dangerous occurrences that happen in various surgical operations. Negative Pressure Therapy (NPT) has been suggested as a method to diminish surgical site infections (SSIs). However, data concerning the effect of this intervention across different types of operations are still lacking.
This meta-analysis aimed to evaluate the effectiveness and safety of NPT in reducing SSIs following various surgical procedures.
A systematic review was conducted to identify all randomised controlled trials (RCTs) published between 2020 and 2023 that investigated the efficacy of NPT in reducing post-operative SSIs across different types of surgeries. The outcome measures included SSI incidences and adverse effects. Quality assessment and data extraction were conducted in accordance with the PRISMA flowchart.
Our meta-analysis included 18 RCTs, encompassing a total of 7,898 patients across different surgical fields such as orthopaedic, gastrointestinal, hepatobiliary, cancer and gynaecology surgeries. The integrated data demonstrated a significant reduction in SSI incidence when comparing the results of NPT application against standard treatment (odds ratio = 0.53; 95% confidence interval = [0.39–0.73], P = 0.0001). This effect remained consistent when subgrouping the studies by different surgical procedures. The safety profile of NPT was found to be acceptable, with no significant increase in adverse effects such as wound dehiscence and hematomas, and a…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 7,898 participants or records.
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