Cross-cohort meta-analysis reveals conserved gut microbiome signatures of insomnia
Abstract
Highlights • Cross-cohort meta-analysis reveals reproducible gut microbiome signatures of insomnia.• Eight conserved gut taxa are consistently associated with insomnia across studies.• A small number of gut microbes drive most insomnia-associated functional shifts.• The Burkholderia-Caballeronia-Paraburkholderia (BCP) complex drives key functions.• Microbial metabolic changes may indirectly shape host immune and neural states.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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