A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs
Abstract
Simple Summary Given that skin allergies and pruritic dermatitis are highly prevalent in dogs, with a lack of reliable treatment methods, a dietary supplement containing a blend of probiotics, prebiotics, vitamins, nutrients and a yeast-derived postbiotic was developed with the potential to promote symptom reduction through dermatological, immune, and gastrointestinal support. To assess the impact of this supplement on clinical signs of allergy and the gut microbiome, which may influence such symptoms, in companion dogs with pruritic dermatitis, a 10-week trial was conducted. The supplement supported faster improvements and resolution of pruritus, with differences seen compared to a placebo group after 2 weeks. Simultaneously, at the end of the trial, the gut microbiome in treated dogs was enriched with three of the supplemented probiotic species, and unhealthy species were reduced. The enrolled client-owned dogs represented a variety of breeds, ages, and sizes with diverse pruritus severity, which may make the results of this trial more applicable to a larger population of dogs with pruritic dermatitis. Future trials should expand upon the use of dietary supplements with multimodal capabilities for the relief of pruritic dermatitis under stricter cohort definitions. Abstract Pruritic dermatitis (PD) is a common presentation of canine allergic skin diseases, with diversity in severity and treatment response due to complex etiopathogenesis. Evidence suggests the gut…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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