The Impact of Enriched Resistant Starch Type-2 Cookies on the Gut Microbiome in Hemodialysis Patients: A Randomized Controlled Trial
Abstract
SCOPE
Resistant starch type-2 (RS2), can mitigate inflammation and oxidative stress in hemodialysis (HD) patients. However, there is still a lack of knowledge on the impact of the RS2 on the gut microbiota community in these patients. Thus, this study aimed to evaluate the effects of enriched RS2 cookies on the gut microbiome in HD patients.
METHODS AND RESULTS
This comprised a randomized, double-blind, placebo-controlled trial of age-, sex-, and BMI-matched patients and controls. The RS2 group received enriched RS2 cookies (16 g/d of Hi-Maize® 260, Ingredion) for four weeks, while the placebo group received cookies made with manioc flour. Fecal microbiota composition was evaluated by the 16S ribosomal RNA gene. Analysis of the microbiota revealed that Pielou's evenness was significantly decreased after RS2 supplementation. Notably, we observed that RS2 intervention upregulated significantly 8 Amplicon Sequencing Variants (ASV's), including Roseburia and Ruminococcus gauvreauii, which are short-chain fatty acids (SCFA) producers. Furthermore, it was associated with the downregulation of 11 ASV's, such as the pro-inflammatory Dialister.
CONCLUSIONS
RS2 intervention for four weeks in HD patients effectively altered SCFA producers in the gut microbiota, suggesting that it could be a good nutritional strategy for patients with CKD on HD. This article is protected by copyright. All rights reserved.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
Read the paper
Related studies
- Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids
- Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome
- Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of patients with Crohn's disease
- Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model
- Immune Impairment Associated with Vitamin A Deficiency: Insights from Clinical Studies and Animal Model Research
- Glyphosate-based herbicides influence antioxidants, reproductive hormones and gut microbiome but not reproduction: A long-term experiment in an avian model
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.