RISE trial: A novel virtually delivered supervised exercise intervention targeting cognitive impairment and gut microbiome in adolescent and young adult (AYA) brain tumor survivors
Abstract
TPS12167
Background:
Up to 45% of AYA brain tumor survivors experience cancer-related cognitive impairment (CRCI) affecting processing speed, attention, working memory, and executive function—domains critically impacting quality of life (QOL). Moderate-intensity exercise can improve cognitive function by enhancing gut microbiome composition and function. However, only 50% of AYA cancer survivors receive any exercise information from medical providers, with 42% actually meeting physical activity recommendations. Considering developmental milestones and the unique needs of AYA brain tumor survivors, tailoring virtually delivered exercise interventions paired with behavioral coaching and supportive care navigation to promote the adoption of a physically active lifestyle may be a promising approach to reducing CRCI through modulation of gut microbiome health. Few randomized controlled trials (RCTs) have examined this type of exercise intervention for AYA brain tumor survivors. Additionally, the influence of the gut microbiome on the relationship between exercise and cognitive function in AYA brain tumor survivors has not yet been studied. To address these gaps, we developed the Remote Implementation of Supervised Exercise (RISE) intervention, a 12-week personalized aerobic and strength training exercise intervention with behavior coaching and supportive care navigation. The RISE trial aims to evaluate feasibility (primary), cognitive and physical activity (secondary), and gut…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 17 participants or records.
Read the paper
Related studies
- Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids
- Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome
- Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of patients with Crohn's disease
- Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model
- Immune Impairment Associated with Vitamin A Deficiency: Insights from Clinical Studies and Animal Model Research
- Glyphosate-based herbicides influence antioxidants, reproductive hormones and gut microbiome but not reproduction: A long-term experiment in an avian model
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.