Effect of an Exclusive Human Milk Diet on the Gut Microbiome in Preterm Infants
Abstract
Key Points Question What is the effect of an exclusive human milk diet on gut microbiota and clinical outcomes in preterm infants? Findings In this randomized clinical trial of 126 preterm infants, there were no significant differences in measures of gut microbial diversity in infants who only received human milk products compared with those receiving bovine milk formula or fortifiers. There were no differences in clinical outcomes. Meaning These findings suggest that human milk products given to preterm infants to supplement a shortfall in mother’s own milk does not affect clinical outcomes via microbial mechanisms.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 126 participants or records.
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