Gut microbiome dynamics and cardiometabolic disease progression: evidence from a secondary data analysis of pooled clinical datasets
Abstract
Purpose Individuals with cardiometabolic disease (CMD) often exhibit decreased microbial alpha diversity and/or differences in beta diversity indices than those without CMD. However, it is unclear if these compositional changes in the gut microbiome are a cause or a consequence of CMD. Research suggests individual bacterial species act as drivers of disease, inducing shifts in microbial community and host metabolism. During this process, large-scale compositional changes can develop secondarily, obscuring the original microbial drivers. This study aimed to characterize the gut microbiota of healthy individuals compared to those with early risk factors for CMD to determine whether specific microbial taxa and community associations exist with early stages of hypertension, vascular dysfunction, dyslipidemia, and overweight/obesity. Procedure Baseline anthropometric, physiological, and gut microbiome data from three clinical studies previously conducted by our research groups were compiled and re-analyzed. Results No differences in alpha and/or beta diversity were observed across CMD parameters. Through a consensus-based differential abundance analysis, we observed that several health-related taxa decreased as CMD levels increased, including Akkermansia, Bacteroides, Bifidobacterium, Blautia, Eubacterium, Lachnospiraceae, Oscillospiraceae, Prevotella, Roseburia, and Ruminococcus. Furthermore, co-occurrence networks of individuals with elevated cardiometabolic parameters showed…
Read the paper
Related studies
- Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids
- Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome
- Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of patients with Crohn's disease
- Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model
- Immune Impairment Associated with Vitamin A Deficiency: Insights from Clinical Studies and Animal Model Research
- Glyphosate-based herbicides influence antioxidants, reproductive hormones and gut microbiome but not reproduction: A long-term experiment in an avian model
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.