Associations between gut microbiome and circulating cytokines: a cross-sectional analysis in the FINRISK 2002 population cohort
Abstract
A growing body of evidence suggests a relationship between gut microbiome and circulating cytokines, yet there is still a lack of large-scale population-based studies investigating gut microbiome-cytokine associations. In this cross-sectional study, we aimed at investigating the associations of gut microbiome (exposure variable) with 45 cytokines and C-reactive protein (CRP) (outcome variables) in the population-based FINRISK 2002 cohort (N = 2,398). Our analyses focused mainly on gut microbiome alpha diversity, beta diversity, differentially abundant taxa, and predicted functions. All statistical models were adjusted for age, sex, BMI, diabetes, and smoking. Using linear modeling, we identified an inverse association of the gut microbial alpha diversity (Shannon index) with CRP (β=-0.062 ± 0.019/standard deviation (SD), False Discovery Rate adjusted p-value (FDR-P) = 0.025), interleukin-8 (IL-8) (β=-0.066 ± 0.021/SD, FDR-P = 0.025), and interferon-γ-inducible protein 10 (IP-10) (β=-0.063 ± 0.02/SD, FDR-P = 0.025). For beta diversity, linear modeling revealed that the first axis of Principal Component Analysis (PCA) describing the most strongly varying parts of the microbial community composition across population was inversely associated with CRP (β=-0.071 ± 0.019/SD, FDR-P = 0.008) and the second axis was inversely associated with macrophage inflammatory protein-1β (MIP-1B) (β=-0.082 ± 0.021/SD, FDR-P = 0.008), and monokine induced by interferon-γ (MIG) (β=-0.071 ±…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 2,398 participants or records.
Read the paper
Related studies
- Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids
- Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome
- Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of patients with Crohn's disease
- Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model
- Immune Impairment Associated with Vitamin A Deficiency: Insights from Clinical Studies and Animal Model Research
- Glyphosate-based herbicides influence antioxidants, reproductive hormones and gut microbiome but not reproduction: A long-term experiment in an avian model
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.