Abstract 751: Gut microbiome and breast cancer: Report from a case-control study in Vietnam
Abstract
The importance of gut microbiome on human health is being increasingly recognized. The gut microbiota may play a critical role in breast cancer etiology, likely through the roles of the gut microbiota in estrogen and nutrient metabolism as well as in immune regulation. However, evidence on associations between breast cancer and gut microbiota is limited and inconsistent. Using resources from the Vietnamese Breast Cancer Case-Control Study (VBCS), we evaluated differences in gut microbiome profiles between women with breast cancer and healthy women. Pre-treatment tool samples of 162 incident breast cancer cases (age: 50.0±9.5) and stool samples of 370 age-matched controls (age: 49.7±9.0) were included in the study. The gut microbiome was measured using shotgun metagenomic sequencing. Differences in gut microbiome α-diversity and β-diversity between breast cancer patients and healthy controls were evaluated via linear regression models and PERMANOVA testing, respectively. Case-control differences in gut microbial taxa abundance were assessed through the differential abundance analysis with adjustment for potential confounders, including age, income levels, residence, menopausal status, reproductive factors, body mass index, comorbidity, dietary intake, and physical activity. An association with a false discovery rate (FDR) <0.1 was considered statistically significant. No significant difference between breast cancer patients and healthy controls was observed for α- and…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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