Prediction of calcium oxalate kidney stones: A comprehensive analysis of clinical and gut microbiome characteristics
Abstract
In recent years, the role of the gut microbiome in stone formation has gained increasing attention. Specifically, certain gut microbes that metabolize oxalate may regulate oxalate levels in the body, thereby influencing the occurrence of kidney stones. This study aims to investigate the clinical characteristics of calcium oxalate stone patients, the composition of their gut microbiome, and the relationship between these factors and stone formation. This study included 159 calcium oxalate stone patients (case group) and 141 healthy controls (control group). Clinical data were collected to analyze differences in body mass index, urinary metabolic markers (urinary oxalate, calcium, and pH), and other indicators between the 2 groups. High-throughput 16S rRNA sequencing was used to compare the diversity and composition of the gut microbiome. Further, correlations between the gut microbiome and clinical metabolic indicators were analyzed, and a risk prediction model for calcium oxalate stones was developed based on clinical and gut microbiome characteristics. Significant differences in body mass index, urinary oxalate concentration, urinary calcium concentration, and urinary pH were observed between the case and control groups. Gut microbiome diversity analysis revealed that the Shannon and Chao1 indices were lower in the case group, and significant differences in microbiome composition were found. The abundance of Proteobacteria and Firmicutes changed significantly, with a…
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