Associations among diet, gut microbiota, and hypertension: a cross-sectional study in Thai subjects
Abstract
Background: Although the link between the gut microbiota and hypertension has been investigated, its specific role in the increasing prevalence of this disease in Thailand, influenced by changing dietary patterns, remains unexplored. This cohort study investigated the association between the gut microbiome and hypertension-related dietary habits in Thai subjects. Methods: The fecal microbiomes of 31 Thai adults, including non-hypertensive (NHT, n = 12) and hypertensive (HT, n = 19) subjects, were grouped and analyzed according to their dietary and medical records. Alpha and beta diversity analyses were performed to determine significant differences (p 2.0 (p < 0.05). Multiple Factor Analysis (MFA) was employed to integrate anthropometric data, dietary consumption, and gut microbiome, enabling the visualization of features driving overall variation. Functional profiles of the gut microbiome were predicted using PICRUSt2 based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) categories. Differential abundance and microbial-functional associations were evaluated using ALDEx2 and HAllA, respectively. Results: Our exploratory analysis suggests that hypertension-related differences are strongly associated with host factors (age and clinical profiles) rather than diet or microbial composition. Key taxonomic signatures of the HT group include the expansion of Phascolarctobacterium and depletion of Alistipes, which relates to anthropometric and blood profiles. Functional…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 31 participants or records.
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