Association of Recreational Physical Activity with Gut Microbiota Diversity and Composition, and Symptom Burden in Crohn’s Disease: A Cross-Sectional Study
Abstract
Objective This study aimed to investigate the potential benefits of physical activity (PA) on patient-reported outcomes (PROs) in individuals with Crohn’s disease (CD) and to examine whether these benefits are associated with gut microbiota. Methods This cross-sectional study included 251 patients with CD from two inflammatory bowel disease centers in China. Participants with CD provided information on their health background, PA, and PROs using the Global Physical Activity Questionnaire (GPAQ) and the Patient-reported Outcome Measurement Information System (PROMIS). Part of participants also provided a single fecal sample for analysis. Latent profile analysis (LPA) was conducted to categorize individuals with CD into classes based on PROs. Metagenomic sequencing was then performed, followed by bioinformatics assessment of taxonomy and diversity metrics. Results LPA identified two PRO patterns: low and high symptoms. Univariate and multivariate analyses indicated that disease activity and sedentary behavior were risk factors for symptom severity, whereas recreational PA, rather than work-and travel-related PA, and income served as protective factors (all p<0.05). After controlling for age, gender, disease activity level, and other covariates, recreational PA explained microbiome diversity in patients with CD (p=0.016). The gut microbiota diversity (alpha or beta) significantly varied between patients with CD and low and high levels of recreational PA (all p<0.05). A total of…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 251 participants or records.
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