Gut Microbiome Perturbations in Patients with Hidradenitis Suppurativa: a Case Series
Abstract
itis suppurativa; IHS4, International Hidradenitis TO THE EDITOR Hidradenitis suppurativa (HS) is a chronic inflammatory condition estimated to affect up to 0.1e4.0% of the global population (Jemec and Kimball, 2015). The disease is characterized by painful, deep-seated nodules in the apocrine glandebearing areas such as the axillary, inguinal, and anogenital regions. The etiology of the disease is likely multifactorial, which may include unregulated inflammatory cytokines, genetic and hormonal factors, and pathogenic microorganisms (Goldburg et al., 2020). HS has been associated with inflammatory bowel disease (IBD), a condition linked to gut microbiota dysbiosis (Phan et al., 2020), and IBD has been associated with the presence and severity of cutaneousmanifestations including erythema nodosum and pyoderma gangrenosum (Roth et al., 2019). Although an altered skin microbiome was associated with disease severity incasesofHS (Naiketal., 2020), the gut microbiome has not been evaluated as a potential driver of disease in these patients. In a pilot case series study, we evaluated the gut microbiome in three subjects with HS with Hurley Stage 2 or 3 and mild-to-moderate HS severity based on the International Hidradenitis Suppurativa Score System compared with three age-matched healthy volunteers (Table 1, Supplementary Table S1). Exclusion criteria included gastrointestinal illness, use of systemic antibiotics or biologics in the past 4 weeks, and history of IBD. Study subjects…
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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